| Autor: |
Harkany, T., Abraham, I., Laskay, G., Timmerman, W., Jost, K., Zarandi, M., Penke, B, Nyakas, Csaba, Luiten, P.G.M. |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Neuroreport, 10(8), 1693-1698. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: |
0959-4965 |
| Popis: |
A putative tetrapeptide beta-amyloid (A beta) antagonist (propionyl-Ile-Ile-Gly-Leu [Pr-IIGL]) based on the [31-34] sequence of A beta was previously shown to rescue astrocytes from A beta-induced membrane depolarization and subsequent long-term elevations of the intracellular Ca2+ concentration in vitro. Here we provide in vivo evidence that the Pr-IIGL tetrapeptide effectively attenuates the excitotoxic action of A beta(1-42) on cholinergic neurons of the rat magnocellular nucleus basalis (MBN). We also demonstrate by means of microdialysis that administration of Pr-IIGL abolished A beta(1-42)induced increases in extracellular aspartate and glutamate concentrations in the MEN, which coincide with a significant preservation of cholinergic MBN neurons and their cortical projections. This neuroprotective effect was associated with preserved exploratory behavior in an open-field paradigm, and improved memory retention in a step-through passive avoidance task. Our data presented here indicate for the first time the efficacy of short, modified functional A beta antagonists in ameliorating A beta excitotoxicity in vivo. NeuroReport 10:1693-1698 (C) 1999 Lippincott Williams & Wilkins. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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