| Autor: |
de Grauw, J. C., Visser-Meijer, M. C., Lashley, F., Meeus, P., van Weeren, P. R., Afd Veterinaire Anesthesiologie, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, dES RMSC, dES AVR |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Equine Veterinary Journal, 48(2), 152. British Equine Veterinary Association |
| ISSN: |
0425-1644 |
| Popis: |
REASONS FOR PERFORMING STUDY: Intra-articular (IA) injection of corticosteroids with or without hyaluronate (HA) has been used for decades in equine practice for treatment of noninfectious synovitis and osteoarthritis. However, to date, no large-scale randomised equine field trials have been reported that address the supposed superior clinical efficacy of the combination of corticosteroid + HA compared with IA injection of corticosteroid alone.\n\nOBJECTIVES: To compare the clinical efficacy of IA triamcinolone acetonide (TA, 12 mg) compared with IA TA (12 mg) + high molecular weight HA (20 mg) in horses with clinical joint disease.\n\nSTUDY DESIGN: Prospective, randomised, parallel, open label, multicentre clinical trial.\n\nMETHODS: Eighty client-owned horses from 13 clinics were included. Lameness and effusion scores were assessed at baseline and 3 weeks after IA treatment. A standardised telephone questionnaire was completed between the owner and consulting veterinarian at 3 months. The primary outcome parameter was clinical success rate, defined as ≥2 grades lameness reduction (on a 0-5 scale) at 3 weeks. Chi-square statistics and binary logistic regression were used to analyse data on an intention-to-treat basis for the 3 week outcome.\n\nRESULTS: The success rate of IA TA 3 weeks after treatment was 87.8%, while that of TA+HA was 64.1% (P = 0.01). Age >13 years was associated with a reduced success rate for the combination treatment (P = 0.004) at 3 weeks. At 3 months, half the horses in each group had returned to their previous level of performance.\n\nCONCLUSIONS: The combination of TA with HA was associated with a lower short-term clinical success rate and a similar medium-term outcome compared with IA TA, with only half of the horses performing at their previous level of exercise after 3 months regardless of treatment group allocation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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