| Autor: |
van der Kleij, Desiree, Latz, Eicke, Brouwers, Jos F. H. M., Kruize, Yvonne C. M., Schmitz, Marion, Kurt-Jones, Evelyn A., Espevik, Terje, de Jong, Esther C., Kapsenberg, Martien L., Golenbock, Douglas T., Tielens, Aloysius G. M., Yazdanbakhsh, Maria |
| Přispěvatelé: |
Cell Biology and Histology |
| Jazyk: |
angličtina |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Journal of biological chemistry, 277(50), 48122-48129. American Society for Biochemistry and Molecular Biology Inc. |
| ISSN: |
0021-9258 |
| Popis: |
Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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