| Autor: |
Coutinho, R. A., Lelie, P. N., Albrecht-van Lent, P., Stoutjesdijk, L., Huisman, J., Kuipers, H., Schut, L. J., Reerink-Brongers, E. E., Reesink, H. W., van Aken, W. G. |
| Přispěvatelé: |
Other departments |
| Jazyk: |
angličtina |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Developments in biological standardization, 54, 287-292. S. Karger AG |
| ISSN: |
0301-5149 |
| Popis: |
The efficacy of a heat-inactivated hepatitis B virus (HBV) vaccine, containing 3 micrograms-HBsAg, was studied among a group of 800 susceptible homosexual men. The trial was conducted randomized, placebo-controlled and double blind. At the trial end point (21.5 months) the attack-rate for all HBV infections together was 4.8% among vaccinees and 23.8% among the placebos (p less than 0.0001). Four months after the first injection 89% of the vaccinees had formed anti-HBs and this percentage declined only slightly during the follow-up period. Maximum titers were reached 5 months after the first vaccination. None of the vaccinees who responded to the vaccine with anti-HBs greater than or equal to 1 mIU/ml developed a HBsAg positive infection. The vaccine had no serious side-effects |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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