Human papillomavirus type influences the extent of chromosomal lag during mitosis in cervical intraepithelial neoplasia grade III

Autor: Burger, MPM, VanLeeuwen, AM, Hollema, H, Quint, WGV, Pieters, WJLM
Přispěvatelé: Targeted Gynaecologic Oncology (TARGON)
Jazyk: angličtina
Rok vydání: 1997
Předmět:
Zdroj: International journal of gynecological pathology, 16(1), 10-14. LIPPINCOTT WILLIAMS & WILKINS
ISSN: 0277-1691
Popis: The level of risk for carcinoma in the uterine cervix depends on the type of human papillomavirus (HPV) present. We examined whether the HPV type influences the proliferation rate and occurrence of mitotic figures with lagging chromosomes in the precursor of cervical carcinoma. The study group comprised 180 women who were referred because of cytologic changes indicating dysplasia and who were subsequently diagnosed with cervical intraepithelial neoplasia grade III. The HPV-16-associated lesions showed a significantly higher number of mitoses per 1,000 nuclei than the lesions without HPV (p
Databáze: OpenAIRE