| Autor: |
Wilders, Ronald, Hoekstra, Maaike, van Ginneken, Antoni C. G., Verkerk, Arie O. |
| Přispěvatelé: |
Medical Biology, Cardiology |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Zdroj: |
Computing in cardiology, 37(37), 629-631. IEEE Computer Society |
| ISSN: |
0276-6574 |
| Popis: |
To assess the role of the slow delayed rectifier potassium current (IKs) in the β-adrenergic modulation of heart rate, we experimentally determined the effect of β adrenergic stimulation on IKs and used the thus obtained data in computer simulations of SA nodal pacemaker activity, employing the mathematical model of a primary rabbit SA node pacemaker cell by Kurata and coworkers. Incorporation of our experimental findings into the SA nodal cell model resulted in a 12 ms decrease in cycle length. This decrease in cycle length is similar to the 13 ms decrease observed upon incorporation of our experimental data on the effect of β-adrenergic stimulation on the hyperpolarization-activated funny current' (If), also known as 'pacemaker current'. We conclude that IKs is an important contributor to the β-adrenergic modulation of heart rate |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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