| Autor: |
Habets, Petra E. M. H., Clout, Danielle E. W., Lekanne Deprez, Ronald H., van Roon, Marian A., Moorman, Antoon F. M., Christoffels, Vincent M. |
| Přispěvatelé: |
Medical Biology, Human Genetics |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Zdroj: |
Journal of muscle research and cell motility, 24(2-3), 205-209. Springer Netherlands |
| ISSN: |
0142-4319 |
| Popis: |
Cardiac expression of a transgene is a common approach for determining the role of gene products in the processes underlying cardiomyopathy and heart failure (HF). We have generated transgenic mice that express the 'harmless' yeast transcription factor Gal4 in the heart under control of the alpha-myosin heavy chain promoter and found that expression of this gene causes cardiomyopathy and HF, the severity of which correlated with the number of copies of the transgene integrated into the genome and with the expression level. A line with a single copy of the transgene targeted to the hprt locus correctly expressed the transgene but did not develop cardiomyopathy. Our results indicate that expression of a transgene in the heart may non-specifically cause HF in a dose-dependent manner |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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