| Autor: |
Portegies, P., Cohen, E. S. |
| Přispěvatelé: |
Neurology |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2002 |
| Zdroj: |
Nederlands tijdschrift voor geneeskunde, 146(30), 1398-1400. Bohn Stafleu van Loghum |
| ISSN: |
0028-2162 |
| Popis: |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with unknown pathogenesis. Loss of motor neurons leads to progressive weakness and, finally, respiratory failure with a mean survival of 3 years. A possible causal role of a retroviral infection has recently been suggested by studies of 7 HIV-infected patients who developed a rapid progressive ALS-like disorder as the first manifestation of their HIV-infection. All patients stabilised or improved with antiretroviral therapy. Other research groups have published on the detection of enterovirus RNA in the spinal cords of ALS-patients, also suggesting a viral aetiology of the disease. The results of these neuro-virological studies warrant further research into the possible role of viral infections as a cause of ALS, as well as clinical trials with anti-retroviral and anti-enteroviral drugs in ALS |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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