ELEVATED CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITY IN IDDM MEN WHO SMOKE - POSSIBLE FACTOR FOR UNFAVORABLE LIPOPROTEIN PROFILE

Autor: DULLAART, RPF, GROENER, JEM, DIKKESCHEI, BD, ERKELENS, DW, DOORENBOS, H
Přispěvatelé: Lifestyle Medicine (LM)
Jazyk: angličtina
Rok vydání: 1991
Předmět:
Zdroj: Diabetes Care, 14(4), 338-341. AMER DIABETES ASSOC
ISSN: 0149-5992
Popis: Objectives: To determine the effect of cigarette smoking on the activity of cholesteryl ester transfer protein (CETP) and high-density (HDL), low-density (LDL), and very-low-density (VLDL) lipoproteins in insulin-dependent diabetic (IDDM) men with microvascular complications. Research Design and Methods: We performed a case-control study in a referral-based diabetes clinic on a sequential sample of 9 cigarette-smoking and 12 nonsmoking IDDM men with microvascular complications and 12 nonsmoking control men. CETP activity was determined in each serum with an isotope assay with exogenous cholesteryl ester-labeled LDL and HDL. The method is independent of the endogenous lipoprotein present in serum. Results: The HDL-cholesterol (VLDL and LDL) ratio was lower in the smoking diabetic men than in the other groups (P
Databáze: OpenAIRE