| Autor: |
Deemter, M. van, Šmisterová, J., Schaaf, G. van der, Meijberg, W., Robillard, G. |
| Přispěvatelé: |
Groningen Biomolecular Sciences and Biotechnology, Enzymology |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Zdroj: |
Journal of Controlled Release, 101(1-3), 342-343. Elsevier Bedrijfsinformatie b.v. |
| ISSN: |
0168-3659 |
| Popis: |
The goal of this study is to develop a controlled methotrexate delivery system that releases its content by a target specific stimulus. To accomplish this, both methotrexate and an engineered channel protein (MscL) were incorporated into DOPC/CH/DSPE-PEG liposomes, providing a controlled drug delivery system. Reconstitution and encapsulation methods were optimized in order to ensure optimal channel gating activity and high drug:lipid ratio. At the optimal conditions, a 95% release of MTX could be reached. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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