| Autor: |
BRUGEMANN, J, VANDERMEER, J, HILLEGE, HL, VANBOVEN, AJ, VANDOORMAAL, JJ, DEGRAEFF, PA, LIE, KI |
| Přispěvatelé: |
Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC) |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
International Journal of Cardiology, 45(2), 109-113. ELSEVIER IRELAND LTD |
| ISSN: |
0167-5273 |
| Popis: |
The aim of this study was to investigate whether failure of thrombolytic treatment might be due to inhibition of fibrinolysis by high lipoprotein(a) levels. Fifty-eight patients with acute myocardial infarction were treated intravenously within 4 h after onset of symptoms with anistreplase (30 units) and heparin (30 000 IU/24 h). Blood samples for measurement of coagulation parameters were taken before and 1.5 h after treatment. Coronary angiography was performed after 48 h. Levels of lipoprotein(a) were measured 6 months after discharge from hospital. The patency rate was 74% (43/58). Median lipoprotein(a) levels were not different between the patients with a patent and those with a non-patent vessel (10 and 8 mg/dl, respectively), however, in patients with a non-patent infarct-related vessel, a significant inverse correlation was found between the lipoprotein(a) level and the decrease of plasminogen in the first 1.5 h after treatment. It is concluded that high lipoprotein(a) levels, although not directly associated with a poor outcome of anistreplase therapy, might contribute to insufficient fibrinolysis in patients with a non-patent infarct-related vessel. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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