| Autor: |
Lindeboom, Lucas, Bruls, Yvonne M.H., van Ewijk, Petronella A., Hesselink, Matthijs K.C., Wildberger, Joachim E., Schrauwen, Patrick, Schrauwen-Hinderling, V.B. |
| Přispěvatelé: |
RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section B, RS: NUTRIM - R1 - Metabolic Syndrome, Beeldvorming, Promovendi NTM, MUMC+: DA Beeldvorming (5), RS: CARIM - R3.11 - Imaging, MUMC+: DA BV Klinisch Fysicus (9) |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Magnetic Resonance in Medicine, 77(2). Wiley |
| ISSN: |
0740-3194 |
| Popis: |
PURPOSE: Acetylcarnitine formation is suggested to be crucial in sustaining metabolic flexibility and glucose homeostasis. Recently, we introduced a method to detect acetylcarnitine in vivo with long TE 1 H-MRS. Differences in T1 relaxation time between lipids and acetylcarnitine can be exploited for additional lipid suppression in subjects with high myocellular lipid levels. METHODS: Acquisition of spectra with an inversion recovery sequence was alternated with standard signal acquisition to suppress short T1 metabolite signals. A proof of principle experiment was conducted in a lean subject and the new approach was subsequently tested in four overweight/obese subjects. RESULTS: Using the new T1 editing approach, lipid signals in spectra of skeletal muscle can be (additionally) suppressed by a factor of 10 using a TI of 900 ms. Combination of the long TE protocol with the T1 editing resulted in a well-resolved acetylcarnitine peak in the obese subjects. CONCLUSION: The T1 editing approach suppresses short T1 metabolites and offers a new contrast in 1 H-MRS. The approach should be used in combination with a long TE in subjects with high lipid contamination for accurate quantification of the acetylcarnitine concentration. Magn Reson Med, 2016. (c) 2016 Wiley Periodicals, Inc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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