| Autor: |
Fockens, P., Mulder, C. J., Tytgat, G. N., Blok, P., Ferwerda, J., Meuwissen, S. G., Tuynman, H. A., Dekker, W., Gasthuis, K., van Hees, P. A. |
| Přispěvatelé: |
Other departments |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Zdroj: |
European journal of gastroenterology & hepatology, 7(11), 1025-1030. Lippincott Williams and Wilkins |
| ISSN: |
0954-691X |
| Popis: |
To investigate a possible dose-effect relationship with two dosages of oral slow-release mesalazine in patients with quiescent ulcerative colitis. One hundred and sixty-nine patients with ulcerative colitis in remission were treated with either 1.5 or 3.0 g/day mesalazine for 1 year or until relapse into active colitis. Fewer of the 3.0 g dose group relapsed than of the 1.5 g dose group (33 compared with 46%). This difference failed to reach statistical significance (P = 0.057). A significant relationship between age and relapse rate was established. No dose-related adverse events were found. Three serious drug-related adverse events were, however, reported. All of the serious adverse reactions resolved after the medication was discontinued. There is a trend for high doses of oral mesalazine to be more effective in prevention of relapse of ulcerative colitis. These higher doses are not associated with a higher incidence of adverse reactions |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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