| Autor: |
MICKLEM, KJ, Dong, Yin, WILLIS, A, PULFORD, KA, Visser, Lydia, DURKOP, H, POPPEMA, S, STEIN, H, MASON, DY |
| Jazyk: |
angličtina |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
The American Journal of Pathology, 139(6), 1297-1301. ELSEVIER SCIENCE INC |
| ISSN: |
0002-9440 |
| Popis: |
The monoclonal antibodies HML-1, B-ly7 and Ber-ACT8 recognize intramucosal gut T lymphocytes, activated cells, and hairy cell leukemia. The antigen on hairy cells consists of three glycoproteins (160kD, 130kD and 105kD unreduced; 145kD and 120kD reduced). These peptides have biochemical features reminiscent of integrins but we have shown by immunoprecipitation that they are not known integrin subunits. We have used a newly produced antibody (BP6) to purify this molecule and shown by N-terminal sequence analysis that the smallest subunit is the product of integrin beta-7 cDNA. This molecule is thus a new member of the integrin family of leucoyte adhesion proteins. Immunoprecipitation experiments indicate that the two larger subunits are recognized by HML-1, B-ly7 and Ber-ACT8. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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