| Autor: |
Wildeboer, R. R., van Sloun, R. J. G., Schalk, S. G., Mannaerts, C. K., van der Linden, J. C., Huang, P., Wijkstra, Hessel, Mischi, M. |
| Přispěvatelé: |
CCA - Imaging and biomarkers, Graduate School, APH - Quality of Care, Urology, APH - Personalized Medicine |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Zdroj: |
IEEE transactions on medical imaging, 37(12), 2593-2602. Institute of Electrical and Electronics Engineers Inc. |
| ISSN: |
0278-0062 |
| Popis: |
Despite being the solid tumor with the highest incidence in western men, prostate cancer (PCa) still lacks reliable imaging solutions that can overcome the need for systematic biopsies. Dynamic Contrast-Enhanced Ultrasound Imaging (DCEUS) allows us to quantitatively characterize the vascular bed in the prostate, due to its ability to visualize an intravenously administered bolus of contrast agents. Previous research has demonstrated that DCE-US parameters related to the vascular architecture are useful markers for the localization of PCa lesions. In this work, we propose a novel method to assess the convective dispersion (D) and velocity (v) of the contrast bolus spreading through the prostate from three-dimensional (3D) DCE-US recordings. By assuming that D and v are locally constant, we solve the convective-dispersion equation by minimizing the corresponding regularized least-squares problem. 3D multiparametric maps of D and v were compared to 3D histopathology retrieved from the radical prostatectomy specimens of six patients. With a pixel-wise area under the Receiver Operating Characteristic curve of 0.72 and 0.80, respectively, the method shows diagnostic value for the localization of PCa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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