| Autor: |
de Hert, S. G., van der Linden, P. J., Broecke, P. W., Rodrigus, I. E., Sermeus, L. A., Moulijn, A. C., Gillebert, T. C. |
| Přispěvatelé: |
Other departments |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Zdroj: |
Anesthesia and analgesia, 89(4), 835-842. Lippincott Williams and Wilkins |
| ISSN: |
0003-2999 |
| Popis: |
Increasing cardiac load by leg elevation identifies patients with load-dependent impairment of left ventricular (LV) function. This impairment is related to a deficient length-dependent regulation of LV function. We investigated the effects of dobutamine on length-dependent regulation of LV function in coronary surgery patients (n = 25). High-fidelity LV pressure tracings were obtained at end-expiration, while hearts were paced at a fixed rate of 90 bpm. Effects of leg elevation on contraction and relaxation were compared before and during dobutamine 5 microg x kg(-1) x min(-1). Effects on contraction were evaluated by analysis of changes in dP/dtmax. Effects on relaxation were assessed by analysis of R (slope of the relation between the time constant of isovolumic relaxation and end-systolic pressure). Correlations were calculated with linear regression analysis using Pearson's coefficient r. The effects of leg elevation on variables of contraction and relaxation were coupled. We found a close relationship between changes in dP/dtmax and individual values of R (r = 0.84; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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