| Autor: |
Mourad, AbdElAziz A. Nayl, Hamada Mohamed Ibrahim, Kamal M. Dawood, Wael A. A. Arafa, Ahmed I. Abd-Elhamid, Ismail M. Ahmed, Mohamed A. Abdelgawad, Hazim M. Ali, Ibrahim Hotan Alsohaimi, Ashraf A. Aly, Stefan Bräse, Asmaa Kamal |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Molecules; Volume 27; Issue 19; Pages: 6369 |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules27196369 |
| Popis: |
An appropriate and efficient Q-tube-assisted ammonium acetate-mediated protocol for the assembly of the hitherto unreported 5-arylazopyrazolo[3,4-b]pyridines was demonstrated. This methodology comprises the cyclocondensation reaction of 5-amino-2-phenyl-4H-pyrazol-3-one with an assortment of arylhydrazonals in an NH4OAc/AcOH buffer solution operating a Q-tube reactor. This versatile protocol exhibited several outstanding merits: easy work-up, mild conditions, scalability, broad substrate scope, safety (the Q-tube kit is simply for pressing and sealing), and a high atom economy. Consequently, performing such reactions under elevated pressures and utilizing the Q-tube reactor seemed preferable for achieving the required products in comparison to the conventional conditions. Diverse spectroscopic methods and X-ray single-crystal techniques were applied to confirm the proposed structure of the targeted compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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