DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes

Autor:	Oliveira, Bernardo Almeida Iglesias, Níckolas Pippi Peranzoni, Sophia Iwersen Faria, Luana Belo Trentin, André Passaglia Schuch, Otávio Augusto Chaves, Renan Ribeiro Bertoloni, Sofia Nikolaou, Kleber Thiago de
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	porphyrins thienyl-porphyrins Pt(II) and Pd(II) complexes DNA photobiology
Zdroj:	Molecules; Volume 28; Issue 13; Pages: 5217
ISSN:	1420-3049
DOI:	10.3390/molecules28135217
Popis:	We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA.
Databáze:	OpenAIRE
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