Self-Reported Systemic Sclerosis-Related Symptoms Are More Prevalent in Subjects with Raynaud’s Phenomenon in the Lifelines Population: Focus on Pulmonary Complications

Autor: Mulder, Saskia Corine van de Zande, Amaal Eman Abdulle, Yehya Al-Adwi, Alja Stel, Karina de Leeuw, Elisabeth Brouwer, Suzanne Arends, Christiaan Tji Gan, Harry van Goor, Douwe Johannes
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Diagnostics; Volume 13; Issue 13; Pages: 2160
ISSN: 2075-4418
DOI: 10.3390/diagnostics13132160
Popis: Puffy fingers and Raynaud’s phenomenon (RP) are important clinical predictors of the development of systemic sclerosis (SSc). We aim to assess the prevalence of SSc-related symptoms, explore pulmonary symptoms, and test the usefulness of skin autofluorescence (SAF) as a non-invasive marker for Advanced Glycation Endproducts (AGEs). Subjects from the Lifelines Cohort Study with known connective tissue disease (CTD) were excluded. Patient characteristics, SAF, self-reported pulmonary symptoms, and spirometry were obtained. Subjects (n = 73,948) were categorized into definite RP (5.3%) with and without SSc-related symptoms and non-RP. Prevalence of at least one potential SSc-related symptom (other than RP) was 8.7%; 23.5% in subjects with RP and 7.1% without RP (p < 0.001). Subjects with RP and additional SSc-related symptoms more frequently reported dyspnea at rest, dyspnea after exertion, and self-reported pulmonary fibrosis, and had the lowest mean forced vital capacity compared to the other groups (RP without SSc-related symptoms and no RP, both p < 0.001). In multivariate regression, dyspnea at rest/on exertion remained associated with an increased risk of SSc-related symptoms in subjects with RP (both p < 0.001). SAF was higher in subjects with RP and SSc-related symptoms compared to the other groups (p < 0.001), but this difference was not significant after correction for potential confounders. The prevalence of SSc-related symptoms was approximately three-fold higher in subjects with RP. Pulmonary symptoms are more prevalent in subjects with RP who also reported additional potential SSc-related symptoms. This might suggest that (suspected) early SSc develops more insidiously than acknowledged. According to this study, SAF is no marker for early detection of SSc.
Databáze: OpenAIRE
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