| Autor: |
Kim, Mi Jung Kwon, Young Rim Song, Joo-Hee Kim, Ji Hee Kim, Ho Suk Kang, Hyun Lim, Min-Jeong Kim, Nan Young Kim, Sangkyoon Hong, Younghee Choi, Kyueng-Whan Min, Hyo Geun Choi, Eun Soo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biomedicines; Volume 11; Issue 6; Pages: 1606 |
| ISSN: |
2227-9059 |
| DOI: |
10.3390/biomedicines11061606 |
| Popis: |
Chronic kidney disease (CKD) and Alzheimer’s disease (AD) are common chronic diseases in the elderly population. Although a relationship between CKD and the occurrence of AD has been proposed, previous research results have been disputed, and further investigation is necessary to confirm this relationship. In this longitudinal follow-up study, we examined data from the Korean National Health Insurance Service-Health Screening Cohort, consisting of 15,756 individuals with CKD and 63,024 matched controls aged ≥40 years who received health check-ups between 2002 and 2019. Overlap-weighted Cox proportional hazard regression models were exploited to calculate hazard ratios (HRs) for the association between CKD and AD. During the monitoring period, individuals with CKD had a greater incidence of AD than those without CKD (15.80 versus 12.40 per 1000 person years). After accounting for various factors, CKD was significantly associated with a 1.14-fold increased likelihood of developing AD, with a 95% confidence interval ranging from 1.08 to 1.20. In subgroup analysis, this relationship persisted irrespective of age (≥70 or |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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