| Autor: |
Stupák, Ivana Večurkovská, Jana Mašlanková, Vladimíra Tomečková, Jana Kaťuchová, Terézia Kisková, Lucia Fröhlichová, Mária Mareková, Marek |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biomedicines; Volume 11; Issue 7; Pages: 1839 |
| ISSN: |
2227-9059 |
| DOI: |
10.3390/biomedicines11071839 |
| Popis: |
Purpose: The development of sensitive and non-invasive biomarkers for the early detection of CRC and determination of their role in the individual stages of CRC. Methods: MMP-9 expression in serum and tissue, and BDNF expression in plasma were detected using the ELISA method. MMP-9 and BDNF in the tissue were also determined by immunohistochemical staining. Results: To assess the balance between changes in survival and tumor progression, we compared BDNF/MMP-9 ratios in tissues of living and deceased individuals. The tissue BDNF/MMP-9 ratio (evaluated immunohistochemically) decreased significantly with the progression of the disease in living patients. The BDNF/MMP-9 ratio was statistically significantly reduced in stages II and III compared to the benign group. However, in deceased individuals, the ratio showed an opposite tendency. Conclusion: The determination of the tissue BDNF/MMP9 ratio can be used as a prognostic biomarker of CRC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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