The BMPR2, ALK1 and ENG Genes Mutation in Congenital Heart DiseaseAssociated Pulmonary Artery Hypertension

Autor:	Hartopo, Anggoro Budi, Anggrahini, Dyah Wulan, Emoto, Noriaki, Dinarti, Lucia Kris
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	gene mutation pulmonary artery hypertension congenital heart disease– associated PAH polycyclic compounds
Zdroj:	ACI (Acta Cardiologia Indonesiana); Vol 5, No 2 (2019); 145-149
ISSN:	2460-5700 2579-4345
Popis:	The gene mutation is one of the background underlie the pathogenesis of pulmonary artery hypertension (PAH). Several genes have been recognized to be responsible for the development of PAH. The mutation in transforming growth factor-β (TGF-β) pathway is considered to be major genotype background in heritable PAH. The genetic mutation in bone morphogenetic protein receptor-2 (BMPR2), activin receptor-like kinase 1 (ALK-1) and endoglin (ENG) are known to cause heritable PAH. In congenital heart disease–associated PAH (CHDAPAH), their mutation are also presence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=jurnalonline::f30ad733143a913081c1f4f3876293a9 https://journal.ugm.ac.id/jaci/article/view/50222 Zobrazit plný text záznamu