Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy
| Autor: | Takenaka, Akira, Yokota, Mitsuhiro, Iwase, Masatsugu, Miyaguchi, Kazuhiko, Hayashi, Hiroshi, Saito, Hidehiko |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | European heart journal. 14(5):669-676 |
| ISSN: | 0195-668x |
| Popis: | To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardi-ography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy controls. Systolic dysfunction started in the first decade of life, with some patients showing severe systolic dysfunction in their early teens. This dysfunction, however, did not always depend on the severity of the skeletal muscle disease. No patients with DMD showed an increase in peak atrial velocity and time-velocity integrals of the atrial contraction velocity curve, findings frequently reported to precede the abnormalities in many cardiac diseases; it was thought therefore that these patients had no increase in left atrial compensation. Diastolic dysfunction may not routinely precede or accompany the systolic dysfunction in DMD, in contrast with what is reported in patients with ischaemic or hypertensive heart disease. DMD patients usually show a predominant systolic dysfunction. 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年2月19日 竹中晃氏の博士論文として提出された |
| Databáze: | OpenAIRE |
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