| Autor: |
Shishito, Sentaro, Shibuya, Shozo, Sasaki, Keiichi, Shibuya, Masayoshi, Kato, Hiroaki, Imabayashi, Kenichi, Ozu, Keisuke, Ohnuma, Tetsutaro, Kaiho, Hiroo, Sugawara, Keiji, Nakano, Nobumichi, Kato, Masakazu, Yamanaka, Masao, Nitta, Kiichi, Matsushita, Shozaburo, Saito, Katsuyuki, Saito, Takeshi, Miyata, Koyo, Takeuchi, Mutsuo, Chiba, Ryuichi, Kurosawa, Masaya, Shio, Nobuo |
| Jazyk: |
japonština |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
泌尿器科紀要. 21(7):681-703 |
| ISSN: |
0018-1994 |
| Popis: |
Cefatrizine (S-640P, 1g/day, p.o.) and ampicillin (AB-PC, 1g/day, p.o.) were administered to 150 cases of acute urinary tract infections, and the efficacy of these drugs was compared with double blind procedure. Except 5 drop-out cases (2 in S-640P, and 3 in AB-PC), which had not visited the hospital after first administration of the drugs, the background of 145 cases were analyzed according to 33 articles, and it was to be satisfied in its uniformity as the subject of this trial. The final evaluation of therapeutic effect of each drug was decided according to the individual evaluation of the effect on urinary microorganism, urinary findings, and general status of the patients, except the side-effect. These results were analyzed statistically, and no significant difference was observed between these evaluations. Furthermore, x2-test, Wilcoxon's procedure, and calculation of several coefficients of correlation were carried out, but any significant difference between the action of these drugs could not be observed. As the side-effect, blister formation on the mucous membrane (1), exanthema (3), diarrhea (2), and slight increase of s-GOT and Al-P-ase (1) were observed in S-640P group; blister formation on mouth lip (1), decrease of neutrophilic leucocyte and increase of lymphocyte (1), exanthema (1), and increase of s-GOT, s-GPT and Al-P-ase (1) were found in AB-PC group. But all of these were slight and temporary, and these needed neither suspension of drug administration nor some available therapies. The clinical efficacy of S-640P was 74.0% on the 4th day of administration and 72.6% on the 8th day of administration, while the efficacy of AB-PC was 69.0% on the 4th day and 76.6% on the 8th day of administration. With the results obtained above, it was concluded that S-640P and AB-PC should have almost the same therapeutic effect on the simple acute urinary tract infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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