| Popis: |
Decrease in bioavailability ofmicronutrients including retinol occurred frequently in patients with diabetes mellitus. We supposed that iron status might relate to glucose metabolism, because vitamin A utilization is inhibited in iron deficiency. To clarify the mechanism of these relationships, following experiment was carried out. Rats were divided into four groups: male wistar-strain rats, which fed the normal diet (N), the iron-deficient diet (ID), the retinol-deficient diet (RD), and Goto-Kakizaki rat (diabetic model rats, GK) fed the normal diet. Every rat was trained to daily meal feeding (9:00-18:00) to measure serum glucose. After 4 weeks of these dietary regiments, serum glucose was higher in iron-deficient rats than the N-group and the RD-group. Hepatic retinol was higher in the ID-group than the GK-group and the N-group. Serum retinol was lower in the ID-group than the GK-group and the N-group. These results suggested that iron deficiency induced glucose intolerance in rats. In conclusion, micronutrients status effect on a diabetic condition |
