Study of levels of latamoxef in prostatic tissue and bladder mucosal tissue
| Autor: | NAKATA, Yasunobu, MIZUNAGA, Mitsuhiro, MORIKAWA, Mitsuru, OSANAI, Hiroaki, FUJISAWA, Makoto, INADA, Fumie, YACHIKU, Sunao |
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| Jazyk: | japonština |
| Rok vydání: | 1987 |
| Předmět: | |
| Zdroj: | 泌尿器科紀要. 33(2):289-293 |
| ISSN: | 0018-1994 |
| Popis: | 前立腺肥大症および膀胱腫瘍患者20例に対して, LMOX 1 gまたは2 gを静注し, 血清, 前立腺および膀胱粘膜組織内濃度について検討した.1) LMOX投与後の血清, 前立腺および膀胱粘膜組織内濃度は, その投与量に応じた良好なdose responseを示した.2)前立腺組織内濃度は良好な値を示しており, さらに膀胱粘膜組織内濃度は有意に高く, またその体血清比も有意に高値を示した.3)前立腺および膀胱粘膜組織内濃度と臨床分離株に対するLMOXのMIC 80値との比較により, 十分な有効濃度がえられた The concentration of Latamoxef (LMOX) in the serum, prostatic tissue and bladder mucosal tissue of 20 patients with benign prostatic hypertrophy and bladder cancer was measured after intravenous infusion of 1 g or 2 g of LMOX. Serum, prostatic tissue and bladder mucosal tissue levels of LMOX responded satisfactorily to the dose of LMOX. The bladder mucosal tissue level was higher than the prostatic tissue levels. Judging from the inhibitory concentration of LMOX (MIC 80), the concentration was sufficiently effective against infections caused by gram-negative, gram-positive and anaerobic bacilli. |
| Databáze: | OpenAIRE |
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