| Autor: |
Kobayashi, Hitomi, Mitani, Mami, Minatogawa, Yuka, Hayashi, Satoko, Nakamoto, Mariko, Shuto, Emi, Nii, Yoshitaka, Sakai, Tohru |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
The Journal of Medical Investigation. 64(1-2):20-23 |
| ISSN: |
1349-6867 |
| Popis: |
Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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