| Autor: |
Makoto, Akutsu, Hiroaki, Kanaya, Takashi, Kashiwagi, Yasuhiro, Tsunemi, Shin-ichi, Haruna |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Dokkyo Journal of Medical Sciences. 47(3):125-136 |
| ISSN: |
0385-5023 |
| Popis: |
Background：Eosinophilic chronic rhinosinusitis（ECRS） is an intractable subtype of chronic rhinosinusitis（CRS）, which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive （MMP-8＋）neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS.Methods：Nasal polyps （NPs）in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8＋ neutrophils in NPs were evaluated in combination with histological and clinical parameters.Results：MMP-8＋ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8＋ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group；however, the percentage of MMP-8＋ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8＋ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8＋ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group.Conclusions：This study suggests that MMP-8＋ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8＋neutrophils might become a candidate of nasal therapeutic target for patients with ECRS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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