バイヨウ ヒト コウコウ ヘンペイ ジョウヒ ガン サイボウ ニオケル TNF-α イゾンテキナ GRO-α ノ ユウドウ GRO-α ニヨル ケッカン シンセイ サヨウ ト シュヨウ ゾウショク サヨウ ニツイテ
| Autor: | Narita, Norihiko, Matsumiya, Tomoh, Kon, Takao, Hayakari, Ryo, Itoh, Ryohei, Kubota, Kosei, Sakaki, Hirotaka, Furudate, Ken, Yoshida, Hidemi, Imaizumi, Tadaatsu, Kobayashi, Wataru, Kimura, Hiroto |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | 弘前医学. 65(2-4):147-155 |
| ISSN: | 0439-1721 |
| Popis: | The CXC chemokine growth-related oncogene protein-α （GRO-α） has a wide variety of biological activities including as neutrophil trafficking or migration of vascular endothelial cells. In addition, studies have shown a crosstalk between tumor cells and vascular endothelial cells; GRO-α released by endothelial cells induces invasion of tumor cells toward endothelial cells, indicating an importance of GRO-α in a tumor environment. Oral squamous cells are reported to produce GRO-α in response to cytokines such as tumor necrosis factor-α （TNF-α）. However, little is known about how GRO-α is involved in oral cancer. Here, we investigated the biological role of GRO-α for both tumor growth and angiogenesis in oral squamous cell carcinoma cells. We first evaluated the effect of TNF-α on GRO-α expression in three oral cancer cells from different origins. Among the cell lines we used, KOSC-2 cells expressed the highest amount of GRO-α mRNA in response to TNF-α. TNF-α-treated condition medium from KOSC-2 cells enhanced endothelial cell chemotaxis and the chemotactic activity was partially inhibited by the addition of neutralizing anti-GRO-α antibody. In addition, GRO-α exerted tumor cell migration of KOSC-2. From these results, we conclude that GRO-α may contribute to both angiogenesis and proliferation in oral cancer. 弘前医学. 65(2-4), 2014, p.147-155 |
| Databáze: | OpenAIRE |
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