Multivariate analyses for prognostic evaluation with C-11 methionine PET/CT for primary non-small-cell lung carcinoma treated by carbon ion radiotherapy
| Autor: | Toubaru, Sachiko, Yoshikawa, Kyosan, Ohashi, Seiya, Hasebe, Mitsuhiko, Ishikawa, Hiroyuki, Tamura, Katsumi, Tanimoto, Katsuyuki, Kandatsu, Susumu, Yamamoto, Naoyoshi, Fukumura, Toshimitsu, Saga, Tsuneo, Kawaguchi, Koji, Hamada, Yoshiki, Kamada, Tadashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Popis: | Purpose: We evaluated whether or not early prediction of the occurrence of local recurrence and metastasis as well as prognosis (disease-specific survival) is possible regarding patients with primary non-small-cell lung cancer treated by carbon ion radiotherapy (CIRT) by PET/CT using L-methyl-[llC]-methionine (MET). Methods: One hundred forty-six cases that underwent MET-PET/CT study prior to CIRT were prospectively investigated. One hundred thirty-one cases of them also underwent second MET-PET/CT study three months following the completion of CIRT. MET accumulation of the tumor was evaluated using the semiquantitative tumor to normal tissue ratio (TNR). A univariate and multivariate analysis were carried out regarding TNR of the tumor as well as several other clinical factors (age, gender, and tumor size). Results: The average TNR prior to treatment and TNR following treatment was 3.8 (2.0) and 2.6 (1.2), respectively, showing a significant decline in the TNR following treatment. Upon univariate analysis, a high TNR prior to treatment was a significant factor for occurrence of local recurrence, metastasis and disease-specific survival. Cut-off values were 4.85 (p=0.006), 2.70 (p=0.02) and 4.51 (p=0.002), respectively. A high TNR following treatment was a significant factor for occurrence of local recurrence (Cut-off value=3.10, p=0.003). In the outcome of multivariate analysis, TNR prior to treatment and age were significant factors influencing the occurrence of metastasis. Regarding disease-specific survival, TNR prior to treatment was the factor with significant influence. TNR following treatment was the factor significantly influencing local recurrence. That is to say, TNR prior to treatment was a significant factor for metastasis and disease- specific survival upon both univariate analysis and multivariate analysis. In the same manner, TNR following treatment was a significant factor regarding local recurrence in both analyses. Conclusion: MET accumulation measured by PET/CT was a factor significantly related to the occurrence of local recurrence and metastasis as well as early prognosis regarding CIRT for primary non-small-cell lung cancer, thus suggesting it is useful for determining therapeutic efficacy. Annual Congress of the European Association of Nuclear Medicine |
| Databáze: | OpenAIRE |
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