PPre-surgery SUV and ADC as prognostic factor for outcome in pancreatic cancer
| Autor: | Tanimoto, Katsuyuki, Yoshikawa, Kyosan, Shiraishi, Takahiro, Inagaki, Eri, Toubaru, Sachiko, Ohashi, Seiya, Obata, Takayuki, Saga, Tsuneo, Watanabe, Kazuhiro, Tsuji, Hiroshi, Ando, Yutaka, Kamada, Tadashi, Miyazaki, Masaru, et.al |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Popis: | Objectives: FDG-PET provides quantitative information regarding the tumor glucose metabolism which is useful for the clinical diagnosis of tumor diseases. A diffusion weighted image (DWI) by MRI can be useful in detecting malignancies similar to FDG-PET imaging. We studied the potential prognostic significance of pre-surgery FDG-PET and MRI in pancreatic cancer. Materials and Methods: Pre-surgery patients with either proven or suspected primary pancreatic cancer underwent a FDG-PET/CT and DWI by MRI. The malignancy or benignancy of excised specimens was pathologically confirmed in all cases. The apparent diffusion coefficient (ADC) was measured with DWI. We obtained standardized uptake value (SUV) in PET image. We can slightly improve SUV by using blood glucose corrected SUV (SUV*g: SUV X blood glucose level). The value of each factor for differential diagnosis of tumor malignancy was determined by receiver operating characteristic (ROC) analysis with suspected pancreatic cancer. Similarly, the predictive value of each factor for 1-year disease-free survival (DFS) and overall survival (OS) were determined by ROC analysis with proven pancreatic cancer. Results: On ROC analysis for differential diagnosis of tumor malignancy, the areas under the curve (AUC) of ADC, SUV and SUV*g were 0.830, 0.855 and 0.892, respectively. We considered that these three factors were good indexes for the diagnosis of tumor malignancy. For DFS, the AUC of ADC, SUV and SUV*g were 0.600, 0.843 and 0.811, respectively. The AUC of SUV and SUV*g were larger than the AUC of ADC. For OS, the AUC of ADC, SUV and SUV*g were 0.573, 0.648 and 0.867, respectively. The AUC of SUV*g was larger than the AUC of ADC and SUV. The SUV and SUV*g of FDG-PET/CT might be better indexes for estimation of prognosis. The 1-year DFS rate above the cutoff (SUV>4.3, SUV*g>400) were markedly lower than the rate below the cutoff (SUV>4.3, SUV*g>400) (0% vs. 67% p400) tended to be lower than the rate below the cutoff (SUV*g>400) (0% vs. 57%, p=0.06). Conclusions: The results of FDG-PET/CT were significantly associated with outcome after definitive therapy of pancreatic cancer. FDG-PET/CT in preoperative evaluation of pancreatic tumor might be useful not only for differential diagnosis of tumor malignancy but also for estimation of prognosis. The 2011 EANM Congress |
| Databáze: | OpenAIRE |
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