| Autor: |
Funazaki, Toshikazu, Aizawa, Yoshifusa, Murata, Minoru, Ebe, Katsuya, Tamura, Makoto, Yamaguchi, Toshio, Fuse, Ichiro, Shibata, Akira |
| Jazyk: |
angličtina |
| Rok vydání: |
1990 |
| Zdroj: |
Acta medica et biologica. 38(4):167-173 |
| ISSN: |
0567-7734 |
| Popis: |
The coronary vasoconstrictive effects of leukotriene D_4 (LTD_4), neuropeptide Y (NPY), angiotensin II, and vasopressin were compared in anesthetized dogs. LTD_4 and NPY of the same molar dose (4.7 nmol) caused equipotent and sustained coronary vasoconstriction in a dose dependent manner. Angiotensin II and vasopressin also showed vasoconstrictor effects, though the dosages used in the experiments were beyond any physiologic range. On the other hand, human polymorphonuclear (PMN) leukocytes, stimulated maximally by arachidonic acids, produced 10-60 ng endogenous leukotriene C_4 (LTC_4) per 10^7 cells, which is also as potent a vasoconstrictor as LTD_4 and the precursor of LTD_4. We concluded that human PMN leukocytes could produce leukotrienes which were sufficient to cause coronary vasoconstriction. This vasoconstriction was seemed important mainly in pathologic situations when PMN leukocytes accumulate around the coronary arteries. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
