| Autor: |
Hirayama, Ryoichi, Furusawa, Yoshiya, Murayama, Chieko, Kusano, Yohsuke, Ito, Atsushi |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Zdroj: |
Radiation Physics and Chemistry. 78(12):1207-1210 |
| ISSN: |
0969-806X |
| Popis: |
To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-20-deoxyguanosine (8-OHdG) in 20-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/mm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/mm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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