| Autor: |
Bing, Wang, Ohyama, Harumi, Nose, Masako, Yukawa, Osami, Yamada, Takeshi, Hayata, Isamu |
| Jazyk: |
angličtina |
| Rok vydání: |
2002 |
| Zdroj: |
Molecular Mechanisms for Radiation-Induced Cellular Response and Cancer Development : Proceeding of the International Symposium on Biological Effects of Low Dose Radiation. :191-194 |
| Popis: |
In the past 5 years, a series of study was done at our institute to investigate radiation effects on the embryogenesis in mice with an emphasis on mechanisms involved in the radiation-induced adaptive response and the role of radiation-induced apoptosis played in teratogenesis in the late period of organogenesis. Using the limb bud system, we first found that radiation-induced apoptosis is involved in malformations, namely, radiation-induced apoptosis in the predigital regions of embryonic limb buds is responsible for digital defects in ICR mice. Examination of embryonic C57BL/6J mice with different p53 status led to further finding that susceptibility to the radiation-induced apoptosis and digital defects depends on both the p53 status and the radiation dose. p53 wild-type mice appeared to be the most sensitive, while p53 knockout mice were the most resistant. These results indicate that p53-dependent apoptosis mediates radiation-induced digital defects. The existence of a radioadaptive response in fetuses, i.e., the priming dose significantly decreases the apoptosis induction, prenatal death, and digital defects in the living fetuses induced by the challenging dose, was found first in ICR strain mice and later confirmed again in C57BL/6J mice. p53 heterozygous embryos did not show the radioadaptive response, indicating the involvement of p53 in the radioadaptive response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
