Thymidine Phosphorylase Expression in Gastric Cancer Tissues is Associated with Thrombocytosis but not with Serum Thymidine Phosphorylase Concentration
| Autor: | Yoshinori, Kikuchi, Masaaki, Ito, Tetsuo, Nemoto, Yajima, Satoshi, Kazue, Shiozawa, Takashi, Suzuki, Yoko, Ooshima, Tatsuki, Nanami, Manabu, Watanabe, Yoshinori, Igarashi, Hideaki, Shimada |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Toho Journal of Medicine. 4(2):66-73 |
| ISSN: | 2189-1990 |
| Popis: | ORIGINAL ARTICLE Background: The relationship of thymidine phosphorylase (TP) expression and patient outcomes has been investigated in various cancers. This study investigated the association of TP expression, serum TP, and platelet counts in patients with gastric cancer. Methods: A series of 77 patients with gastric adenocarcinoma were enrolled in the study. Pretreatment serum TP was determined by enzyme-linked immunosorbent assay and the patient characteristics, including platelet count, gender, age, tumor stage and histological grade, and immunoreactivity of surgically resected tissue specimens, were recorded. Results: The serum TP level was significantly higher in poorly differentiated and signet ring cell adenocarcinomas than in more differentiated types. TP expression was observed within well- and moderately differentiated adenocarcinoma cancer cells, but was significantly weaker in poorly differentiated adenocarcinomas and signet ring cell carcinomas. There were no significant differences in the survival of patients with different histological types and serum TP levels. Although the differences were not statistically significant, high TP expression and high platelet counts were poor prognostic factors. TP expression was not correlated with serum TP levels, but was slightly correlated with the platelet count. Conclusions: TP expression in gastric cancer tissue was slightly related to the platelet count rather than to the serum TP concentration. Therefore, a larger number of patients should be evaluated to assess the relationship between platelet count and capecitabine treatment response in gastric cancer patients. |
| Databáze: | OpenAIRE |
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