Synthesis of antimalarial bicyclic peroxides possessing alkaloidal substituents

Autor: Kamata, Masaki, Okano, Eri, Miyajima, Aya, Hayakawa, Jun, Kim, Hye-Sook
Jazyk: japonština
Rok vydání: 2022
Předmět:
Zdroj: 新潟大学教育学部研究紀要 自然科学編. 14(2):73-90
ISSN: 1883-3845
Popis: Various cyclic peroxides such as 1,4-diaryl-2,3-dioxabicyclo[2.2.2]octane derivatives and 1,5-diaryl-6,7-dioxabicyclo[3.2.2]nonane derivatives possessing alkaloidal substituents were synthesized to evaluate antimalarial activity. In vitro evaluation of the 1,5-diaryl-6,7-dioxabicyclo[3.2.2]nonane derivatives showed high antimalarial activity and high selectivity.
Databáze: OpenAIRE