Synthesis of antimalarial bicyclic peroxides possessing alkaloidal substituents
Autor: | Kamata, Masaki, Okano, Eri, Miyajima, Aya, Hayakawa, Jun, Kim, Hye-Sook |
---|---|
Jazyk: | japonština |
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | 新潟大学教育学部研究紀要 自然科学編. 14(2):73-90 |
ISSN: | 1883-3845 |
Popis: | Various cyclic peroxides such as 1,4-diaryl-2,3-dioxabicyclo[2.2.2]octane derivatives and 1,5-diaryl-6,7-dioxabicyclo[3.2.2]nonane derivatives possessing alkaloidal substituents were synthesized to evaluate antimalarial activity. In vitro evaluation of the 1,5-diaryl-6,7-dioxabicyclo[3.2.2]nonane derivatives showed high antimalarial activity and high selectivity. |
Databáze: | OpenAIRE |
Externí odkaz: |