The effect of DRAMA on estimating human nuro-receptor binding potential with PET
| Autor: | Shiraishi, Takahiro, Kimura, Yasuyuki, Itou, Hiroshi, Ishii, Noriyuki, Iwakami, Hideki, Maeda, Takamasa, Tanimoto, Katsuyuki, Ohashi, Seiya, Toubaru, Sachiko, Yoshikawa, Kyosan, Takano, Harumasa, Tsuji, Hiroshi, Ando, Yutaka, Kamada, Tadashi, Shibayama, Kouichi |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Popis: | Objectives: FBP is a standard method for quantitative analysis in human neuroreceptor binding assay, while OS-EM is used widely in tumor PET imaging. Owing to noise propagation from projection data, especially at high subset number, OS-EM leads to loss of signal to noise (SNR) and quantitative accuracy. A novel reconstruction algorithm DRAMA can suppress the noise propagation by using dynamic relaxation parameter with faster convergence compared to OSEM algorithm. In this study, we compared regional radioactivity concentrations and binding potential (BP) values between FBP, OS-EM and DRAMA to assess the effect of DRAMA algorithm on estimating human nuroreceptor binding. Methods: The PET scanning was carried out with Eminence Sophia(shimadzu corp.) . After 4min pre-injection transmission scan, [11C] FLB457, 90min dynamic PET scans were performed with 3D acquisition mode. To compare reconstruction parameter, a phantom scan was done with same scan protocol. Images were reconstructed with FBP, OSEM and DRAMA to assess quantitative accuracy and noise characteristics. Results: To evaluate the SNR, we performed the image quality tests along with NEMA NU-2 2007. Noise of DRAMA was 7% lower than that of FBP. On the other hands, Q10/N10 number of DRAMA was 5.3% higher than that of FBP,similarly, it is 3.5% higher than that of OS-EM. In patient study, the difference of BP by OSEM with iteration 4, subset 16 compared to FBP was+3.17% at maximum in the caudate, while that of DRAMA was +1.59%. Conclusions:There were no significant differences of BP values in thalamus,frontal cortex, temporal cortex and occipital cortex between DRAMA and FBP. Furthermore, noise propagation was not shown in DRAMA in phantom studies. These results indicated that DRAMA could provide similar performance of FBP with the improved SNR, therefore, DRAMA can be a novel standard reconstruction method of neuroreceptor PET studies. EANM'13 - Annual Congress of the European Association of Nuclear Medicine |
| Databáze: | OpenAIRE |
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