健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル
| Autor: | Nobunao, IKEWAKI, Toru, SONODA, Yasushi, MIYAZAWA, Shin, ONIZUKA, Masayuki, CHIKAMORI |
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| Přispěvatelé: | 九州保健福祉大学生命医科学部生命医科学科・順正学園免疫学研究所, 九州保健福祉大学保健科学部作業療法学科・順正学園免疫学研究所, 九州保健福祉大学保健科学部視機能療法学科・順正学園免疫学研究所, Department of Medical Life Science, Kyushu University of Health and Welfare School of Medical Life Science, Institute of Immunology, Department of Occupational Therapy, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology, Department of Orthoptics and Visual Science, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | 九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 19:87-94 |
| Popis: | 健常人（15名）におけるβ-1,3-1,6 glucan（BG）特異抗体と免疫バイオマーカーの血清レベルを自主開発した酵素抗体法（enzyme immunoassay：EIA）を用いて検討した。その結果、健常人血清中にはBG特異IgG、IgA2およびIgMが恒常的に存在することが分かった。次に、BG特異抗体と免疫バイオマーカーとの相関性を検討したところ、BG特異IgMは血清総IgMと強い相関（r=0.914、P In this clinical study, we examined the serum levels of β-1,3-1,6 glucan (BG)-specific antibodies (IgG,IgA2 and IgM) and the peripheral blood (PB) levels of immune biomarkers, including the serum totalimmunoglobulin (IgG, IgA and IgM), interleukin-6 (IL-6), IL-12 and soluble-form CD44 (sCD44), in 15normal individuals, using an originally developed enzyme-linked immunoassay (EIA). We found that thesera of even normal healthy individuals consistently contain BG-specific IgG, IgA2 and IgM, and that thetiters of these antibodies vary widely among individuals. However, the serum titers of BG-specific IgMwere strongly and significantly correlated with the serum total IgM titers (r = 0.914, P < 0.001).Furthermore, the serum titers of BG-specific IgG were significantly correlated with the serum levels ofsCD44 (r = 0.611, P = 0.015), and the serum titers of BG-specific IgA2 were significantly correlated withthe serum levels of IL-6 (r = 0.588, P = 0.021). In addition, the serum titers of BG-specific IgG, IgA2 andIgM showed a tendency to be correlated with the serum levels of IL-12 (r = 0.449, P = 0.081; r = 0.429, P= 0.092; r = 0.473, P = 0.070, respectively). Taken together, these findings show that normal human seraconsistently and naturally contain BG-specific IgG, IgA2 and IgM. Since the titers of these BG-specificantibodies are correlated with the serum levels of some immune biomarkers, it may be surmised thatthey are closely associated with various immunological responses in the living body to maintain a normalhealth condition. |
| Databáze: | OpenAIRE |
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