Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography
| Autor: | Tsubo, Toshihito, Fujita, Ayaka, Hashiba, Eiji, Ishihara, Hironori, Hirota, Kazuyoshi |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | 弘前医学. 59:S128-S136 |
| ISSN: | 0439-1721 |
| Popis: | application/pdf To investigated the eff ect of high volume continuous hemofi ltration（ HVHF） on the lung lesion observed with transesophageal echocardiography （TEE） in endotoxin-induced acute lung injury in piglets. Piglets weighing 20-30kg. Interventions: After endotoxin of 20 μg/kg intravenous administration, animals were randomly assigned to control group（ n=7） and HVHF group（ n=7）. In both group, fi ltration was performed for fi ve hours and zero balanced. Filtration fl ow was 150 ml/hr in HVHF group and 0ml/hr in control group. The area of the lesion, resistive index and maximal blood velocity in regional pulmonary artery were estimated using TEE. High mobility group B1 protein （HMGB1）, cortisol and catecholamine concentrations were measured in plasma at endotoxin 5 hours. Measurements of blood gas, hemodynamics and TEE images were obtained every hour. The value of PaO2, density area and resistive index were 70.0±8.8 mmHg, 10.7±4.5 cm2 and 0.61±0.23 in control group and 120.4±20.3 mmHg, 3.3±2.0 cm2 and 0.88 ±0.22 in HVHF group at endotoxin 5 hours respectively（ mean±SD）. PaO2 and resistive index increased, and density area decreased in HVHF group than those of control group signifi cantly（ p 弘前医学. 59(Suppl.), 2007, p.S128-S136 |
| Databáze: | OpenAIRE |
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