| Autor: |
Matsushita, Hiroshi, Ikeda, Fusao, Iwasaki, Yoshiaki, Seki, Hiroyuki, Nanba, Shintaro, Takeuchi, Yasuto, Moritou, Yuki, Yasunaka, Tetsuya, Onishi, Hideki, Miyake, Yasuhiro, Takaki, Akinobu, Nouso, Kazuhiro, Yamamoto, Kazuhide |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Journal of Gastroenterology and Hepatology. 29(2):337-343 |
| ISSN: |
0815-9319 |
| Popis: |
Background and Aim: Chronic infection with hepatitis C virus (HCV) decreases health-related quality of life (HRQOL). The present study was planned to investigate the impact of HRQOL of patients with chronic hepatitis C (CHC) on the outcomes of therapy with pegylated interferon and ribavirin (RBV), in addition to IL28B polymorphisms. Methods: The present study enrolled 228 CHC patients and assessed their HRQOLs prospectively with the 36-item short-form health survey. Results: The patients with CHC have lower physical HRQOL status than the general population (P = 0.037, the Z-test). The patients with advanced liver diseases exhibited further decreases in HRQOL (P = 0.036, Spearman's rank correlation coefficient). The score of total HRQOL was significantly lower in the group with sustained virological response (SVR) to the therapy with pegylated interferon and RBV than the non-SVR group (P = 0.031, the Mann-Whitney U-test), with significantly lower scores of mental component and its comprising subscales in the SVR group. Stepwise multivariate logistic regression analysis showed that low HRQOL score |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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