| Autor: |
MAEDA, KIYOSHI, OYA, HIROSHI, YAMADA, KEIKO, YAMAMOTO, JUNNOSUKE, NAKASHIMA, MITSUYOSHI, SEKIYA, ATSUSHI |
| Jazyk: |
angličtina |
| Rok vydání: |
1970 |
| Zdroj: |
Nagoya Journal of Medical Science. 32(3-4):453-458 |
| ISSN: |
2186-3326 |
| Popis: |
Acute toxicity and pharmacological actions of rosolic acid were studied. Results: (1) LD 50 s of rosolic acid on mice were 82 (78-87) mg/kg s.c. and 49 (41-58) mg/kg i.p. The animals survived after the oral administration. (2) Significant irritation on the mucosa was not observed. (3) Rosolic acid produced a rise in the blood pressure and a transient depression of respiration in the rabbit. (4) Rosolic acid increased the contractile force and heart rate in the isolated atria of the guinea pig. (5) Rosolic acid caused a contraction followed by a relaxation in the isolated rabbit and guinea pig ileum. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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