Gastric emptying capacity test by 13C breath test using semi-solid test meal : Report of preliminary data by healthy volunteers

Autor: KAIDA, Sachiko, TAKEBAYASHI, Katsushi, OHTAKE, Reiko, URANO, Ayumi, NISHIDA, Kaori, KURIHARA, Mika, MURAMOTO, Keiji, MATSUNAGA, Takashi, MORI, Haruki, TOKUDA, Aya, MAEHIRA, Hiromitsu, HIGASHIGUCHI, Takayuki, KOJIMA, Masatsugu, UEKI, Tomoyuki, MIYAKE, Toru, YAMAGUCHI, Tsuyoshi, IIDA, Hiroya, SASAKI, Masaya, TANI, Masaji
Jazyk: japonština
Rok vydání: 2022
Předmět:
Zdroj: 滋賀医科大学雑誌. 35(1):16-19
Popis: 背景：胃癌の治療においては根治切除手術が必要不可欠であるが、近年は早期胃癌、高齢者の増加に加え、腹腔鏡手術やロボット支援下手術による低侵襲化が進んでいる。一方で胃切除術後の体重減少やダンピング症候群などの生活の質を低下させる「胃切除後障害」が問題となっている。目的：本試験は流動食のみでなく実際に患者が食すであろう食事にできるだけ近づけた形態の半固形食を作成し、健常volunteerに服用してもらい13C-acetate呼気試験を行うことで胃排出能の評価を行うことである。方法：試験は過去に行われた同様の13C-acetate呼気試験と同様に行い、食事は半固形食を使用することで過去の報告の液状食、固形食との胃排出速度との違いを比較した。結果：健常volunteerは年齢45(40–58)歳、男性:女性=5:15、BMI 23.1(20.2-30.5) kg/m2。Cmaxの中央値は32.4 (16.2 – 44.1) (‰), T1/2の中央値は36.8 (13.0 – 75.4)分であった。試験食摂取前から摂取240分までの呼気中の13CO2排出変化量を測定したところ、ピークは摂取後60分であった。過去の同様の研究報告と比較すると、液状食でピークは摂取後30分、固形食では80分といずれとも異なる結果であった。結語：健常volunteerにおいて半固形食を摂取した後の胃排出能は固形食、液状食いずれの結果とも異なるものであった。
Background:Radical resection surgery is essential in the treatment of gastric cancer. However, in recent years, in addition to an increase in the number of early-stage gastric cancers and elderly patients, minimally invasive surgery using laparoscopic or robotic gastrectomy has become popular. With this, post-gastrectomy syndromes that reduce patients’ quality of life, such as weight loss and dumping syndrome, have become a problem. However, the mechanism responsible for these disorders remains unclear. Purpose: In this study, we prepared not only a liquid diet but also a semi-solid diet that was as close as possible to the actual diet that patients would eat. Materials and Methods: The 13C-acetate breath test was performed as described in other studies with a semi-solid diet, and the difference in gastric evacuation rate between the liquid and solid diets reported in previous studies was compared. Results: Forty-five healthy volunteers were included (age range: 40–58 years, male: female = 5:15, Body Mass Index [BMI] 23.1 [range: 20.2–30.5] kg/m2). The median Cmax and median T1/2 was 32.4 (range: 16.2–44.1) ‰ and 36.8 (range: 13.0–75.4) minutes, respectively. The change in 13CO2 emission in exhaled air from before to 240 minutes after ingestion of the test meal was measured, with the peak being 60 minutes after ingestion. A similar study reported the peaks occurred 30 and 80 minutes after ingestion for the liquid and solid diets, respectively. Conclusion: Gastric emptying in healthy volunteers after ingestion of a semi-solid diet differed from that after ingestion of solid or liquid diets—the original diets. In the future, more gastric cancer patients must be evaluated in comparative studies.
Databáze: OpenAIRE
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