DNA metabolism of prostate. 3. Effects of sexual hormones upon DNA metabolism in normal rat's prostatic gland and during development of experimental prostatic tumors

Autor:	KAZUTA, Minoru
Jazyk:	japonština
Rok vydání:	1967
Předmět:	Male Estradiol/pharmacology Prostate/drug effects/metabolism DNA/biosynthesis Animals Autoradiography 494.9 Prostatic Neoplasms/metabolism Testosterone/pharmacology Neoplasms Experimental/chemically induced/metabolism Methylcholanthrene Rats
Zdroj:	泌尿器科紀要. 13(1):3-17
ISSN:	0018-1994
Popis:	Effects of sexual hormones on the anterior lobe of the pro s tatic glands in male rats of the Wistar strain were examined by means of histological alterations and DNA synthetic patterns. Then the similar studies were performed on the effects of sexual hormones during development of prostatic tumors following injection of 20-methylcholanthrene. Administration of either testosterone propion a te 0.05mg or estradiol benzoate 0.002mg daily for 6 days per week demonstrated marked difference in histological alterations between the both hormones during 120 day's observation, while no significant difference was seen in radioautographic patterns. Administr a t ion of the above hormones following injection of 20-methylcholanthrene proved that the histological as well as autoradiographic alterations are significantly different between the both hormones. The finding suggested that female sexual hormone seems accelerate the development of experimental tumor in the rat's prostatic gland.
Databáze:	OpenAIRE
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