| Autor: |
Hashimoto, Hajime, Ishimoto, Takayuki, Konishi, Hayato, Hirokane, Tsukasa, Wakamori, Shinnosuke, Ikeuchi, Kazutada, Yamada, Hidetoshi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Zdroj: |
Organic letters. 22(17):6729-6733 |
| ISSN: |
1523-7060 |
| Popis: |
Herein, a practical synthesis of the macaranoyl group contained in ellagitannins, i.e., a C-O digallate structure with a tetra-ortho-substituted diaryl ether bond, is described. The methodology involved an oxa-Michael addition/elimination reaction between a brominated ortho-quinone monoketal and a phenol with a hexahydroxydiphenoyl moiety in the presence of 18-crown-6 under dark conditions, followed by reductive aromatization. The existence of rotamers originating from the constructed ether moiety is discussed as well. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
