| Autor: |
Iwasa, Junkichi, Kawanishi, Tetsuroh, Handa, Satoshi, Kamano, Hideki, Yamamoto, Shingo, Okamoto, Manabu, Takeda, Norimasa, Nakamura, Mikihiko, Masutani, Tetsuya, Shiro, Motoo, Nakajima, Shuhei, Baba, Naomichi, Seyama, Issei |
| Jazyk: |
angličtina |
| Rok vydání: |
1992 |
| Zdroj: |
岡山大学農学部学術報告. 79(1):1-35 |
| ISSN: |
0474-0254 |
| Popis: |
Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from α-dihydro GTX- 11 . These new compounds and the previously prepared GTXS ere directly applied to the intracellular phase of internally perfused squid giant axons. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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