Predictive Factors for Late Rectal Toxicity in Prostate Cancer Patients after Intensity Modulated Radiation Therapy
| Jazyk: | japonština |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | 信州医学雑誌. 71(3):159-165 |
| ISSN: | 0037-3826 |
| Popis: | Purpose : To identify predictive factors for late rectal toxicity in prostate cancer patient who underwent intensitymodulated radiation therapy (IMRT). Methods : 415 prostate cancer patients who underwent IMRT between November 2008 and September 2019 were included. All patients underwent definitive radiation therapy with a total prescribed dose of 78 Gy, and 2 Gy per fraction. We analyzed the relationship between late rectal toxicity and the following factors : National Comprehensive Cancer Network (NCCN) risk classification, use of anticoagulants, radiation methods and various dose-volume histogram parameters. Results : Median follow-up period was 46 months (3-133). Grade ≥ 2 late rectal adverse events occurred in 8.0 ％ (n＝33). Univariate analysis revealed that NCCN high-risk group (P＝0.026) and low percentage of bladder wall volume irradictaed 70 Gy or more to total bladder wall volume (BW V70Gy％) were significantly associated with increased rate of Grade ≥ 2 late rectal toxicity (P＝0.026 and 0.036, respectively). Multivariate analysis showed that both of them were independently accociated with the rate of the toxicity (P＝0.016 and 0.033, respectively). Conclusion : NCCN high-risk group and low BW V70Gy％ might be predictive factors for Grade ≥ 2 late rectal toxicity. Article 信州医学雑誌 71(3) : 159-165, (2023) |
| Databáze: | OpenAIRE |
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