Popis: |
The effects of various anti-cancer agents, such as mitomycin C (MMC), 5-fluorouracil (5-FU), diethylstilbestrol (DES) and alpha-naphthyl-isothiocyanate(ANI) on rat kidney tumor induced by dimethylnitrosamine (DMN) were studied. In rats receiving DES and ANI, the development of kidney tumors was inhibited. Histologically, golden-brownpigments were observed in the cells of renal tubules in the groups of DES-treatment. No significant effects of the other anti-cancer agents were observed on the DMN-induced rat kidney tumors. |