| Autor: |
Masayuki, Fujinaga, Ohkubo, Takayuki, Tomoteru, Yamasaki, Katsushi, Kumata, Nobuki, Nengaki, Zhang, Ming-Rong |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Zdroj: |
Organic Letters. 24:4024-4028 |
| ISSN: |
1523-7052 |
| Popis: |
Scandium triflate-catalyzed N-[18F]fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin ([18F]2) was investigated. This reaction is mild and provides one-step access to N-[18F]fluoroalkylated aryl- or heteroaryl-amines, which are used for positron emission tomography imaging. Use of 2,2,2-trifluoroethanol as a cosolvent improved the re-action efficiency. The use of (S)- or (R)-[18F]2 produced the corresponding enantiomeric N-[18F]fluoroalkylated anilines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
