Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy

Autor: Oda, Seiko, Kobayashi, Shigeki, Nanno, Takuma, Ishiguchi, Hironori, Myoren, Takeki, Murakami, Wakako, Mochizuki, Mamoru, Oda, Tetsuro, Okuda, Shinichi, Yamada, Jutaro, Okamura, Takayuki, Matsuzaki, Masanori, Yano, Masafumi
Rok vydání: 2016
Předmět:
Zdroj: The bulletin of the Yamaguchi Medical School. 63(1-2):5-16
ISSN: 0513-1812
Popis: We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients
Databáze: OpenAIRE