妊婦のLactobacillus rhamnosus GG ヨーグルト摂取による乳児期早期の腸内Bifidobacteirum 属菌形成促進
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | 東邦医学会雑誌. 61(1):3-12 |
| ISSN: | 0040-8670 |
| Popis: | 原著 Background: Recent studies have found associations between maternal probiotic consumption and early growth of healthy intestinal flora in their newborns. We gave probiotics to mothers during late pregnancy and compared changes in the intestinal flora of their newborns. Methods: Thirty pregnant women were given 100 gof yogurt containing Lactobacillus rhamnosus GG(LGG)from the start of the 33rd week of gestation until parturition(LGG group), and the results obtained from their newborns were compared with those from infants born to 20 mothers who had not received this probiotic treatment. Reverse-transcriptase polymerase chain reaction was used to evaluate the presence and number of bifidobacteria in newborn meconium and in stool after receiving colostrum, at discharge from hospital, and at ages 1, 4, and 6 to 9 months and 1 year. Results: The LGG group had higher bifidobacteria detection rates, a greater number and variety of flora, and higher detection rates of Bifidobacterium breve. In particular, the bifidobacteria detection rate was significantly higher in the LGG group(p=0.008). Conclusions: Giving LGG yogurt probiotics to pregnant women during late pregnancy significantly increased and maintained bifidobacteria growth in the intestinal flora of their newborns, especially from the start to the end of weaning. 目的: 妊娠後期の母体にプロバイオティクスを摂取させ,出生した児の腸内細菌叢の変化を比較検討した.対象および方法: 妊娠33週の妊婦30例にLactobacillus rhamnosus GG(LGG)ヨーグルト(菌)を出産まで毎日1個摂取させた群をLGG群,摂取していない妊婦20例を対象群とした.出生した児の便中のBifidobacterium属菌をreverse-transcriptase polymerase chain reaction(RT-PCR)を用いて定量し経過観察した.検査の時期は,胎便,初乳後,退院時,生後1, 4, 6〜9カ月,1歳で行った.結果: LGG群の方が,Bifidobacterium属菌の検出率,菌数,菌種数,およびBifidobacterium breve(B. breve)の検出率が高く,とくにBifidobacterium属菌の検出率はLGG群で有意に高かった(p=0.008).考察: 妊娠後期の母体が,LGGヨーグルトでプロバイオティクスを摂取し,児の離乳初期から離乳後期におけるBifidobacterium属菌優位の腸内細菌叢の形成が促進され,その後も維持された. |
| Databáze: | OpenAIRE |
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